Methods and Tools for Detection and Evaluation of the Risks of Porcine Endogenous Retrovirus in Porcine to Human Xenotransplantation
نویسندگان
چکیده
Xenotransplantation has been defined by the Public Health Service as any procedure that involves the transplantation, implantation, or infusion into a human recipient of either (a) live cells, tissues, or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs (PHS 2001). The promise of xenotransplantation is to provide a replenishable, controlled source of cells, tissues, and organs, in order to alleviate the chronic shortage available for human allotransplantation.
منابع مشابه
Identification of receptors for pig endogenous retrovirus.
Xenotransplantation of porcine tissues has the potential to treat a wide variety of major health problems including organ failure and diabetes. Balanced against the potential benefits of xenotransplantation, however, is the risk of human infection with a porcine microorganism. In particular, the transmission of porcine endogenous retrovirus (PERV) is a major concern [Chapman, L. E. & Bloom, E. ...
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